Anti-MAP2K4 Antibody

This polyclonal reagent from Antibodies.com targets MAP2K4 (also called MKK4, SEK1, or JNKK1), a dual-specificity kinase positioned at the apex of stress-activated MAPK cascades. By phosphorylating JNK and p38 MAP kinases, MAP2K4 couples upstream stress inputs to transcriptional programs controlling apoptosis, inflammatory cytokine production, and cell-cycle checkpoint responses in tumor suppression contexts.

Affinity-purified from rabbit hosts and prepared as an unconjugated IgG isotype in a 200 µl liquid format, the antibody is validated for Western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation workflows. Reactivity has been confirmed against Human, Mouse, and Rat samples, supporting comparative studies in cell culture lysates, tumor xenograft tissue sections, and primary rodent tissue models used by signal transduction and cancer biology laboratories.