Anti-MAP2 Antibody

Microtubule-associated protein 2 (MAP2) is a somatodendritic cytoskeletal regulator that stabilizes dendritic microtubules and modulates synaptic plasticity in developing and mature neurons. This rabbit polyclonal antibody from Antibodies.com is raised against MAP2 and unconjugated, supplied as 100 µl of polyclonal antiserum for use in western blot and immunofluorescence workflows.

The reagent reacts with human, mouse, and rat MAP2, and in immunofluorescence it labels dendritic arbors and neuronal soma while sparing axonal processes, supporting clear morphological discrimination between neuronal compartments. On western blots of neural tissue lysates, it resolves the high-molecular-weight MAP2a and MAP2b isoforms characteristic of mature neurons, enabling studies of cytoskeletal remodeling, neurite outgrowth, and differentiation status.

Researchers apply this antibody to characterize neuronal differentiation in stem cell-derived cultures, validate induced pluripotent stem cell (iPSC)-derived neurons, map dendritic pathology in injury models, and benchmark neuronal markers in mixed neural cultures. For best results, aliquot upon receipt, store refrigerated, and avoid repeated freeze-thaw cycles to preserve antibody activity. Each vial is intended for single use experimental sessions once opened.