Anti-MAOA Antibody

Produced in rabbit hosts and supplied in a 100 µL volume, this unconjugated polyclonal reagent from Antibodies.com is raised against monoamine oxidase A (MAOA), a flavin adenine dinucleotide-dependent enzyme anchored to the outer mitochondrial membrane. The antibody is validated for Western blot and immunohistochemistry on human and mouse specimens, supporting both denatured protein analysis and fixed-tissue localization studies.

MAOA catalyzes the oxidative deamination of monoamine neurotransmitters, including serotonin, norepinephrine, epinephrine, and dopamine, making it a focal target in neurotransmitter metabolism research. Investigators apply this reagent to characterize expression patterns in models of mood disorders, aggression-related behaviors, Parkinson's disease, and select cancers where altered MAOA levels correlate with tumor progression. The MAOA gene maps to Xp11.3 on the short arm of the X chromosome, and the encoded protein migrates near 60 kDa on SDS-PAGE.

Because MAOA is a membrane-associated multi-transmembrane protein, empirical optimization of detergent conditions in lysis buffers and antigen retrieval parameters for IHC is recommended. The polyclonal format presents multiple epitopes, which can enhance signal in tissues with low target abundance. Aliquot upon receipt to limit freeze-thaw cycles and preserve reagent performance across repeated experiments.