Anti-MAN1B1 Antibody

This rabbit polyclonal antibody specifically targets MAN1B1 (Mannosidase Alpha Class 1B Member 1), an endoplasmic reticulum-resident alpha-1,2-mannosidase involved in glycoprotein quality control and ER-associated degradation pathways. The unconjugated antibody is supplied by Antibodies.com in a 100 µl volume and is validated for Western blot (WB) and immunohistochemistry (IHC) applications.

MAN1B1 plays a central role in trimming N-linked glycans during protein folding and trafficking through the secretory pathway. Pathogenic variants in MAN1B1 are associated with a congenital disorder of glycosylation known as MAN1B1-CDG, sometimes called ERMAN syndrome, which presents with intellectual disability, characteristic facial features, and metabolic abnormalities. Researchers studying glycosylation biology, endoplasmic reticulum stress, and related neurodevelopmental disorders use this reagent to probe MAN1B1 expression in human samples.

The polyclonal antibody recognizes multiple epitopes across the MAN1B1 target, supporting detection across varied experimental conditions. The unconjugated format allows flexible downstream labelling, including chromogenic and fluorescence detection workflows in fixed and frozen tissue sections.