Anti-MAD2L1 Antibody

Raised in rabbit and unconjugated, this polyclonal antibody targets the MAD2L1 protein, a core component of the mitotic spindle assembly checkpoint (SAC). MAD2L1 sequesters CDC20 to inhibit the anaphase-promoting complex/cyclosome (APC/C), ensuring proper chromosome alignment before anaphase onset. The reagent performs in Western blot, immunohistochemistry, and immunofluorescence assays and cross-reacts with human, mouse, and rat samples, supporting cell cycle and cancer research focused on chromosomal instability, mitotic regulation, and checkpoint signaling.

Supplied as 100 µl of antiserum in a vial, this antibody from Antibodies.com should be stored at -20 °C and aliquoted into single-use portions to limit freeze-thaw cycles. Protect from light and avoid repeated freeze-thaw cycles to preserve binding affinity. Researchers studying mitosis, kinetochore function, or tumor suppressor pathways can use this reagent to characterize MAD2L1 expression across mammalian model systems.