Anti-M6PR Antibody

Raised in rabbit against the cation-independent mannose-6-phosphate receptor (M6PR), this unconjugated polyclonal antibody from Antibodies.com ships as a 100 µl vial and is validated for western blot and immunohistochemistry on human samples. M6PR (also called IGF2R) is a large type I transmembrane glycoprotein that sorts acid hydrolases bearing mannose-6-phosphate tags from the trans-Golgi network to late endosomes and lysosomes, and it independently binds extracellular IGF2, linking lysosomal biogenesis to growth-factor clearance and tumor-cell signaling. Investigators apply this reagent to studies of receptor trafficking, endosomal sorting, and IGF2R expression patterns in cultured cells and paraffin-embedded tissue, with western blot resolving the ~250 kDa full-length receptor and IHC highlighting Golgi, endosomal, and plasma-membrane staining in human specimens. Aliquot on receipt and store refrigerated protected from light; the product is for research use only.