Anti-LYZ Antibody

This rabbit polyclonal primary antibody from Antibodies.com binds human lysozyme (LYZ), a ~14 kDa cationic antimicrobial enzyme of the innate immune system that cleaves the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in bacterial peptidoglycan walls. The unconjugated IgG reagent is supplied as 100 µl of polyclonal serum, validated for Western blot and immunohistochemistry workflows on human tissue and cell samples.

LYZ is highly expressed by Paneth cells of the small intestinal crypts, by granulocytes, monocytes, and macrophages, and is secreted into tears, saliva, and breast milk. Because of this restricted expression pattern, it is routinely used in pathology as a histiocytic and myeloid lineage marker in tumor phenotyping and in studies of granulomatous inflammation. Single-residue mutations in the LYZ gene cause hereditary systemic lysozyme amyloidosis, a rare autosomal dominant condition characterized by deposition of variant lysozyme in the kidneys, liver, and spleen, and the protein has also been investigated as a biomarker in gastric pathology and chronic inflammatory disease.

The polyclonal format recognizes multiple epitopes across the mature lysozyme polypeptide, supporting detection of denatured target in Western blot lysates and of antigen-retrieved epitopes in formalin-fixed paraffin-embedded sections during immunohistochemistry. Researchers working on innate immunity, antimicrobial peptide biology, myeloid cell differentiation, and amyloidosis mechanisms will find this reagent suitable for both protein expression profiling and tissue-level localization studies in human specimens.