Anti-LY96 Antibody

This rabbit polyclonal reagent from Antibodies.com targets LY96 (also known as MD-2), an essential accessory glycoprotein that pairs with TLR4 on the surface of immune cells to enable recognition of bacterial lipopolysaccharide. Raised in rabbit and supplied unconjugated, the antibody is validated for western blot and immunohistochemistry on human samples. The 100 µl volume is sufficient for several full mini-gel blots or a long series of paraffin sections, suiting labs working on TLR4 signaling, sepsis models, gram-negative endotoxin response, and myeloid cell activation.

LY96/MD-2 is required for proper cell-surface expression of TLR4 and for ligand-triggered downstream signaling through both MyD88-dependent and TRIF-dependent pathways, so faithful detection of this co-receptor is critical when interpreting innate immune readouts. Researchers studying endotoxin tolerance, pattern recognition receptor biology, and inflammatory cytokine release benefit from the broader epitope coverage that a polyclonal reagent offers, while the unconjugated format leaves secondary antibody choice and detection chemistry flexible for both membrane and tissue applications.