Anti-LRPAP1 Antibody

Supplied unconjugated in a 100 µl vial, this rabbit polyclonal reagent from Antibodies.com is validated for Western blot and immunohistochemistry detection of LRPAP1, a chaperone protein involved in LDL receptor trafficking and lipid homeostasis. LRPAP1 (Low Density Lipoprotein Receptor Related Protein Associated Protein 1), also called RAP, escorts members of the LDL receptor family through the secretory pathway and prevents premature ligand interaction with nascent receptors in the endoplasmic reticulum. Loss of LRPAP1 in mice upregulates hepatic lipid metabolism pathways, and altered expression has been reported in hepatocellular carcinoma and glioblastoma, supporting its use as a marker in cardiovascular and oncology research. The reagent reacts with the human target and cross-reacts with mouse and rat samples, enabling translational studies across common rodent models. Store refrigerated, protect from light, and aliquot to limit freeze-thaw cycles.