Anti-LRP (MVP) Antibody

Raised in rabbits and supplied at 100 µl as an unconjugated polyclonal reagent, this Antibodies.com primary antibody targets Major Vault Protein (MVP), also referred to as Lung Resistance-Related Protein (LRP), a ~110 kDa ribonucleoprotein component associated with multidrug resistance phenotypes in cancer research.

The antibody is validated for western blot, immunohistochemistry, and immunofluorescence workflows on human samples, supporting investigations of vault particle biology and chemoresistance mechanisms. Relevant applications include studies of non-small cell lung cancer, ovarian carcinoma, and glioblastoma, where elevated MVP expression has been linked to reduced sensitivity to doxorubicin and other chemotherapeutic agents. The unconjugated format permits flexible downstream labeling with fluorophores, biotin, or enzymes for both cell line and paraffin-embedded tissue workflows.

Store at -20°C in small working aliquots to minimize freeze-thaw cycles and preserve binding activity across multiple uses; brief 4°C storage is appropriate for active aliquots.