Anti-LRAT Antibody

The LRAT enzyme (lecithin retinol acyltransferase) anchors retinoid metabolism by esterifying retinol for storage, and this unconjugated rabbit polyclonal IgG from Antibodies.com is raised against the human target for Western blot and immunofluorescence workflows. Supplied as a 200 µl liquid aliquot, the antibody reacts with both human and rat samples, supporting studies of retinal pigment epithelium biology, hepatic stellate-cell vitamin A storage, and retinoid-pathway oncology research.

Validation in immunofluorescence allows direct visualization of LRAT distribution in retinal and hepatic tissue sections, while the Western blot application supports comparative expression analysis across cell lines and primary cultures. The polyclonal IgG format increases the chance of detecting the target even when a single epitope is occluded by post-translational modification or chemical fixation, an advantage when working with limited biopsy or animal-model material.

Investigators commonly deploy this reagent when probing how LRAT loss-of-function variants, dietary retinoid status, or tumor-microenvironment cues reshape vision-cycle flux, hepatic retinyl ester pools, and cellular differentiation states.