Anti-LPXN Antibody

This rabbit polyclonal reagent from Antibodies.com targets LPXN (Leupaxin), a 68 kDa focal adhesion protein in the paxillin family that participates in integrin signaling, cytoskeletal organization, and cell-matrix interactions in hematopoietic lineages and prostate-derived cells. The unconjugated IgG format is supplied as a 50 µl vial and is validated for western blot applications across human, mouse, and rat samples.

Leupaxin is preferentially expressed in B-lymphocytes, macrophages, and osteoclasts, where it functions as a scaffold at focal adhesions linking integrins to downstream signaling cascades. Researchers studying bone resorption, leukocyte adhesion and migration, or prostate cancer cell behavior can use this antibody to detect endogenous LPXN in whole-cell lysates under standard reducing SDS-PAGE conditions. The polyclonal format provides multi-epitope recognition, supporting reliable immunoblotting of the target protein alongside appropriate loading controls and chemiluminescent visualization.

For optimal stability, store the vial refrigerated and protected from light, aliquot upon first use to minimize freeze-thaw cycles, and briefly centrifuge before opening to recover the full volume. The unconjugated design permits pairing with HRP- or fluorophore-conjugated anti-rabbit secondary antibodies of the researcher's choice. Each lot is quality-controlled for western blot performance on representative lysates.