Anti-LPAR4 Antibody

Raised in rabbit as a polyclonal IgG preparation, this unconjugated primary antibody targets LPAR4 (Lysophosphatidic Acid Receptor 4), a G protein-coupled receptor that couples to intracellular signaling cascades triggered by extracellular lysophosphatidic acid. Manufactured by Antibodies.com, the reagent is validated for Western Blot (WB) and Immunohistochemistry (IHC) workflows and cross-reacts with human, mouse, and rat samples, supporting research into receptor-mediated signaling, vascular development, and tumor microenvironment studies.

Supplied as a 50 µl liquid aliquot, the antibody recognizes multiple epitopes on the LPAR4 protein, which helps detection in tissue sections and in cell or tissue lysates where post-translational modification or splice variation may mask individual linear determinants. LPAR4 function is distinct from the better-characterized LPAR1 to LPAR3 receptors, contributing to immune cell chemotaxis, blood–brain barrier permeability, and modulatory roles in neuronal development, which makes selective immunological detection valuable for pathway dissection rather than pan-LPAR profiling.

Applications include immunoblotting of membrane-enriched fractions and immunohistochemistry on formalin-fixed paraffin-embedded or frozen sections, with the unconjugated format allowing flexible pairing with secondary detection reagents for chromogenic or fluorescence-based readouts. The polyclonal profile increases tolerance for minor sequence variation between species orthologs, an advantage when comparing rodent models with human tissue archives in translational pipelines.