Anti-LPAR4 Antibody

Rabbit polyclonal IgG antibody raised against lysophosphatidic acid receptor 4 (LPAR4), a G protein-coupled receptor that binds lysophosphatidic acid (LPA) and modulates cell adhesion, migration, and cytoskeletal dynamics in multiple tissues. This unconjugated primary antibody from Antibodies.com is supplied as 100 µl of liquid reagent and is validated for Western blot and immunohistochemistry workflows. Reactivity data confirm detection of human, mouse, and rat LPAR4 orthologs.

LPAR4, originally designated GPR23, signals through Gα12/13 and Rho-GTPase pathways rather than Gq/11-mediated calcium mobilization, distinguishing it from LPAR1–3 and making it a target for studies of non-canonical LPA signaling. Published applications include immunohistochemistry of Schwann cells during peripheral nerve myelination, Western blot analysis of vascular endothelial tissue in mouse models, and expression profiling of melanoma cell lines where LPAR4 has been associated with altered adhesion and invasive behavior. The reagent is provided as an IgG fraction from rabbit serum, suitable as a primary reagent for chromogenic or fluorescent detection on fixed sections and immunoblots.