Anti-LIMK1 (phospho T508) + LIMK2 (phospho T505) Antibody

Raised in rabbit, this polyclonal IgG antibody from Antibodies.com specifically recognizes the phosphorylated activation loop of LIMK1 at threonine 508 and LIMK2 at threonine 505, the two conserved residues whose modification by upstream kinases such as ROCK and PAK activates these actin-regulatory kinases. The unconjugated reagent is supplied as 50 µl of antiserum and is validated for Western Blot detection of the phosphorylated targets in human samples. Researchers can use this reagent to monitor activation-state changes in the LIMK-cofilin pathway during cytoskeletal remodeling, cell migration, and neuronal development, including responses to stimulation or pharmacological inhibition. For storage, the contents should be kept refrigerated and handled in aliquots to limit freeze-thaw cycles, and the reagent is intended for research use only.