Anti-LIG3 Antibody

This rabbit polyclonal antibody from Antibodies.com targets LIG3 (DNA Ligase III), an ATP-dependent enzyme that seals single-strand DNA breaks during base excision repair. The unconjugated reagent is supplied as 100 µl of polyclonal serum raised in rabbit, validated for western blot, immunohistochemistry, and immunofluorescence workflows. It cross-reacts with human, mouse, and rat samples, enabling comparative studies across model systems. LIG3 partners with XRCC1 at nuclear repair foci and is independently targeted to mitochondria via an alternative N-terminal translation start, supporting investigations into genomic stability, mitochondrial DNA maintenance, and the cellular response to oxidative DNA damage. Research groups working on neurodegeneration, cancer biology, and DNA damage response pathways use this reagent to probe ligase expression in tissue sections and cell lysates.