Anti-LGR6 Antibody

The LGR6 receptor is a leucine-rich repeat-containing G-protein coupled receptor recognized as a marker of adult stem cells in skin, hair follicles, and several epithelial niches. Antibodies.com provides this unconjugated rabbit polyclonal reagent for detecting human LGR6 in Western blot, immunofluorescence, and ELISA workflows. The antibody is supplied as a 100 µl liquid volume that supports multiple experimental runs.

LGR6 belongs to the same receptor family as LGR4 and LGR5 and acts as an R-spondin receptor that potentiates Wnt/β-catenin signaling, making antibodies to this target valuable for studying intestinal crypt homeostasis, hair follicle cycling, and tumor stem cell populations. Polyclonal recognition of multiple epitopes allows consistent detection of LGR6 across different human tissue samples.

For immunofluorescence on frozen or fixed sections, the unconjugated format lets researchers pair the antibody with a preferred secondary reagent, which is helpful when working with multi-color panels aimed at distinguishing LGR6-positive stem cells from differentiated neighbors. Standard Western blot protocols pair this reagent with HRP-conjugated secondaries to detect endogenous receptor levels in cell lysates prepared from human cell lines or primary tissue.