Anti-LGI3 Antibody

The rabbit polyclonal antibody from Antibodies.com targets LGI3 (Leucine-rich glioma-inactivated 3), a secreted member of the LGI/epitempin protein family predominantly expressed in neural tissue. This unconjugated IgG reagent is validated for Western Blot (WB) applications on human samples.

Supplied as 100 µl of polyclonal antiserum, the antibody enables detection of endogenous LGI3 in cell lysates and tissue homogenates. The unconjugated format provides flexibility to pair it with a preferred secondary antibody or label, including HRP, fluorophore, or biotin conjugates.

LGI3 belongs to a small family of secreted leucine-rich repeat proteins (alongside LGI1, LGI2, and LGI4) that have been linked to neuronal migration, Schwann cell signaling, and melanoma cell proliferation. Research-grade antibodies such as this one support neuroscience, cancer biology, and signal transduction studies investigating LGI3 expression patterns and downstream pathways.

For reliable immunoblotting, aliquot the antibody upon arrival and store at -20°C to limit freeze-thaw cycles. Working dilution should be optimized empirically based on the sample type and detection system.