Anti-LETMD1 Antibody

LETMD1 is a mitochondrial outer membrane protein increasingly studied for its role in cancer biology and cellular metabolism. This unconjugated rabbit polyclonal antibody from Antibodies.com targets LETMD1 and is validated for Western blot, immunohistochemistry, and immunofluorescence workflows, supporting detection across human, mouse, and rat sample sources. The polyclonal format provides recognition of multiple epitopes on the LETMD1 protein, which can improve signal consistency in tissues where expression levels are modest, such as renal and hepatic specimens examined in published translational research.

The reagent is supplied as 100 µl of unconjugated antisera, allowing researchers to conjugate it to their preferred fluorophore or enzyme, or to apply it directly in chromogenic detection protocols. Cross-reactivity with mouse and rat orthologs enables comparative work between patient-derived samples and rodent disease models, particularly in investigations linking LETMD1 expression to clear cell renal cell carcinoma prognosis and to hepatocellular carcinoma progression. For immunohistochemistry, antigen retrieval conditions should be optimized to the specific tissue; for Western blot, sample preparation in mitochondrial-enriched fractions can enhance detection of this membrane-associated target.

Storage at -20 °C in working aliquots is recommended to limit freeze-thaw cycles and preserve antibody activity across repeated experiments.