Anti-LEPR Antibody

This polyclonal reagent from Antibodies.com targets the human leptin receptor, a type I cytokine receptor central to leptin signaling and hypothalamic regulation of appetite and energy balance. Raised in rabbit and supplied as 100 µl of unconjugated antiserum, it was generated to detect recombinant LEPR protein and reacts with human samples in both Western blot and immunohistochemistry workflows. The antibody recognizes determinants on LEPR, allowing detection of multiple receptor isoforms including the long signaling form and truncated soluble variants frequently studied in metabolic disease and obesity research. Validated use spans Western blot of cell and tissue lysates alongside immunohistochemistry on fixed sections, supporting receptor localization studies in cultured endocrine cell models and patient-derived specimens. The unconjugated format leaves conjugation chemistry open, so the antibody can be paired with HRP, biotin, or fluorescent reporters in tailor-made staining protocols. For handling, aliquot on arrival and store at -20°C in smaller working volumes; this protects activity across repeated freeze-thaw cycles and keeps the 100 µl supply viable across long-term projects.