Anti-LEPR Antibody

Raised in rabbit against the human leptin receptor (LEPR), this polyclonal primary antibody from Antibodies.com is supplied as a 100 µl unconjugated liquid aliquot validated for western blot and immunohistochemistry applications. LEPR is a class I cytokine receptor that mediates the physiological actions of the adipokine leptin, a key regulator of energy homeostasis and body weight.

Researchers in metabolic disease, neuroendocrinology, and obesity research apply the antibody to tissue sections, cultured cell lines, and whole-cell lysates, supporting studies of JAK/STAT signaling downstream of leptin binding. Because the polyclonal host response recognizes multiple epitopes across the receptor, the reagent can detect both the long signaling form (Ob-Rb) and shorter soluble isoforms found in circulation, aiding investigations into leptin sensitivity and resistance in human samples.

Standard antibody handling is recommended: aliquot upon arrival to limit freeze-thaw cycles, store refrigerated at short-term working temperatures, and protect from light. The unconjugated format allows flexible pairing with HRP, fluorophore, or biotin-labeled secondary reagents in both chromogenic and fluorescence detection workflows in research use only studies.