Anti-LEP Antibody

This polyclonal antibody targets the LEP gene product, also known as leptin, a 16 kDa adipokine secreted primarily by white adipose tissue that regulates energy homeostasis, food intake, and body weight through hypothalamic signaling. Raised in rabbit and supplied as an unconjugated reagent at 100 µl, the antibody is validated for Western blot (WB) and immunohistochemistry (IHC) workflows and shows reactivity against human, mouse, and rat samples. Researchers studying obesity, metabolic syndrome, type 2 diabetes, anorexia, and reproductive endocrinology use LEP detection to characterize leptin expression in serum, tissue sections, and cell lysates. The polyclonal format offers broader epitope coverage than monoclonal alternatives, increasing the likelihood of detecting leptin even when individual epitopes are masked by fixation, denaturation, or post-translational modification. Investigators working on adipocyte biology, neuroendocrine feedback loops, and inflammation-associated metabolic dysregulation will find this Antibodies.com reagent useful for reproducible band patterns on western blots and clean chromogenic staining in formalin-fixed paraffin-embedded tissue.