Anti-LBP Antibody

This polyclonal antibody from Antibodies.com targets lipopolysaccharide-binding protein (LBP), a soluble acute-phase glycoprotein secreted primarily by hepatocytes that mediates innate immune recognition of Gram-negative bacterial endotoxin. By capturing and transferring LPS to CD14 and downstream TLR4 signaling complexes, LBP is a focal molecule in sepsis research, inflammation biology, and host-pathogen interaction studies.

Raised in rabbit and supplied unconjugated in a 100 µl vial, the reagent is validated for western blot and immunohistochemistry on human samples. The antibody enables detection of endogenous LBP expression in tissue sections and in cell or tissue lysates, supporting investigations into acute-phase responses, septic shock pathophysiology, and biomarker discovery. For research use only.

For best results, refrigerate upon arrival and aliquot to avoid repeated freeze-thaw cycles; this preserves polyclonal reactivity against the full-length LBP molecule, including recognition of multiple epitopes that can be valuable when working with samples carrying post-translational modifications or single-residue variation.