Anti-LAYN Antibody

This rabbit polyclonal IgG antibody from Antibodies.com targets LAYN (Layilin), a ~55 kDa single-pass transmembrane glycoprotein that functions as a cell-surface receptor for hyaluronic acid. Produced in rabbit and supplied as 50 µl of unconjugated antiserum, the reagent is validated for Western blot detection of endogenous Layilin in human and mouse samples. In recent literature, Layilin has emerged as a surface marker distinguishing exhausted tumor-reactive CD8⁺ T cells from resting or activated counterparts, supporting research applications in tumor immunology, immune checkpoint biology, and studies of chronic T cell dysfunction. The unconjugated IgG format allows flexible pairing with HRP- or fluorophore-conjugated secondary antibodies in standard chemiluminescent or fluorescent Western blot workflows on PVDF or nitrocellulose membranes. Each vial is intended for research use only and is suited to reproducible detection across established cell lines, primary tissues, and in vitro cell culture models investigating Layilin expression, hyaluronan binding, and downstream cytoskeletal signaling.