Anti-LATS1 Antibody

This rabbit polyclonal IgG reagent targets LATS1 (Large Tumor Suppressor Kinase 1), a serine/threonine kinase that sits at the core of the Hippo signaling cascade and phosphorylates the YAP/TAZ transcriptional co-activators to restrain proliferation and drive apoptosis. The unconjugated antibody from Antibodies.com detects endogenous total LATS1 across Human, Mouse, and Rat samples, supporting comparative work between murine disease models and human tissue specimens in cell culture and in vivo contexts.

Validated for Western blot and immunohistochemistry, the reagent is supplied as 100 µl of polyclonal antiserum raised in rabbit and purified by antigen affinity methods, with a formulation buffered in PBS containing 0.05% sodium azide and 50% glycerol. Researchers studying tumor biology and the Hippo pathway use it to monitor kinase expression, assess pathway activation status, and compare LATS1 levels between normal and malignant tissue, including breast, ovarian, and soft-tissue sarcoma studies where LATS1 loss has been mechanistically linked to tumor progression and cytokinesis defects.

For handling, aliquot the antibody upon arrival and store at -20°C to limit freeze-thaw cycles, and the reagent is intended for research use only.