Anti-LAT Antibody

Antibodies.com offers this rabbit polyclonal antibody raised against LAT (Linker for Activation of T Cells), a 36–38 kDa transmembrane adapter protein essential for T cell receptor signaling. Upon TCR engagement, LAT becomes phosphorylated on tyrosine residues and serves as a scaffold for Grb2, Gads, and phospholipase C-γ1, nucleating the signaling complex that drives downstream calcium flux, MAPK activation, and cytokine production.

Provided as 100 µl of unconjugated antiserum, this polyclonal reagent is validated for western blot and immunohistochemistry on human samples. The antibody recognizes the native human LAT protein and supports studies of T cell activation, immune synapse formation, and signaling events downstream of the T cell receptor in lymphoid tissue sections and cultured cell lysates.

Researchers investigating thymocyte development, peripheral T cell responses, or the molecular basis of immune deficiency will find this reagent useful for tracking LAT expression and phosphorylation status across normal and disease contexts. Brief centrifugation before use is recommended, and small aliquots may be stored at -20 °C in working volumes to limit freeze-thaw cycles of the polyclonal stock.