Anti-LAMP2 Antibody

Lysosomal Associated Membrane Protein 2 (LAMP2) is a heavily glycosylated type I transmembrane protein that constitutes one of the major components of the lysosomal membrane. The Antibodies.com rabbit polyclonal anti-LAMP2 antibody is an unconjugated primary reagent raised against this target and validated for western blot (WB) and immunohistochemistry (IHC) workflows on human samples. Supplied as 100 µl of antiserum, it supports research into lysosome biology, chaperone-mediated autophagy, and the trafficking of substrates destined for lysosomal degradation.

LAMP2 contributes to the fusion of autophagosomes with lysosomes, and loss-of-function mutations in the LAMP2 gene are linked to Danon disease, an X-linked lysosomal storage disorder characterized by hypertrophic cardiomyopathy, skeletal myopathy, and intellectual disability. Researchers studying autophagy flux, membrane protein turnover, or Danon disease models commonly use anti-LAMP2 antibodies as a lysosomal compartment marker alongside complementary autophagy probes such as LC3 and p62/SQSTM1.

Produced in rabbit and provided unconjugated, this polyclonal reagent can be paired with a secondary antibody of the researcher's choice for chromogenic or fluorescent detection. The 100 µl vial format supports multiple western blot and immunohistochemistry experiments depending on working dilution. Standard handling includes aliquoting upon arrival to limit freeze-thaw cycles, with refrigerated short-term storage and frozen long-term storage to preserve antibody activity. For research use only.