Anti-LAMP1 Antibody

The LAMP1 target, Lysosomal Associated Membrane Protein 1, is a heavily glycosylated single-pass type I transmembrane protein that anchors the lysosomal membrane and serves as a standard reference marker in autophagy, endosomal-lysosomal trafficking, and lysosomal storage disorder research. Antibodies.com supplies this rabbit polyclonal reagent as a 50 µl vial at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.3, unconjugated and validated for western blot detection across human, mouse, and rat samples. The antibody is generated in rabbit and recognizes the mature LAMP1 glycoprotein band that typically runs at the high molecular weight position characteristic of this heavily glycosylated lysosomal membrane constituent under standard SDS-PAGE and immunoblotting conditions. The polyclonal format provides broader epitope coverage than monoclonal alternatives, which can be useful when comparing LAMP1 expression across species or when post-translational modifications alter antibody recognition. Researchers investigating chaperone-mediated autophagy, phagosome maturation, and endocytic pathway function will find the unconjugated format compatible with HRP- or fluorophore-conjugated secondary antibodies of their choice. For storage, keep refrigerated, avoid repeated freeze-thaw cycles, protect from light, and aliquot upon first use to preserve long-term activity.