Anti-Laminin gamma-2 Antibody

This rabbit polyclonal antibody from Antibodies.com specifically recognizes Laminin gamma-2 (LAMC2), a basement membrane glycoprotein that forms the gamma-2 chain of laminin-332 (also known as laminin-5). The unconjugated reagent is supplied in a 100 µl volume and is validated for western blot (WB) and immunohistochemistry (IHC) on human samples, supporting studies of epithelial-stromal interactions, hemidesmosomal adhesion, and tumor invasion biology.

Laminin gamma-2 expression is frequently examined as a marker of invasive behavior in squamous cell carcinoma, pancreatic ductal adenocarcinoma, and other solid tumors, where its presence at the invasive front correlates with epithelial-mesenchymal transition. Researchers also apply this reagent to investigate wound healing, inherited skin blistering disorders such as junctional epidermolysis bullosa, and developmental patterning of epithelial basement membranes.

Produced in rabbit as a polyclonal reagent, the antibody binds multiple epitopes on the LAMC2 target, delivering consistent signal in formalin-fixed paraffin-embedded tissue sections for IHC and in denatured whole-cell lysates for WB. For short-term storage, keep refrigerated; for longer-term use, aliquot the contents into single-use tubes to limit freeze-thaw cycles and preserve reagent performance across repeated experiments.