Anti-Lamin B1 Antibody

Lamin B1 is a key nuclear envelope intermediate filament protein that anchors chromatin to the inner nuclear membrane, making antibodies against it essential tools for studying nuclear architecture, cell division, and chromatin organization. This rabbit polyclonal reagent from Antibodies.com is raised against the B-type lamin and recognizes an epitope conserved across species, with validated reactivity against human, mouse, and rat samples in Western blot, immunohistochemistry, and ELISA workflows.

Researchers commonly deploy it as a nuclear envelope counterstain in immunofluorescence, as a normalization control in fractionation studies of nuclear versus cytoplasmic compartments, and as a marker of differentiated cell states in tissue sections. The unconjugated format allows flexible pairing with HRP, biotin, or fluorophore-conjugated secondary reagents depending on the detection chemistry required by each experiment.

Supplied as 100 µl of polyclonal antiserum suitable for research use only, the antibody supports reproducible detection of the 66-68 kDa Lamin B1 band in Western blot of whole-cell lysates, with the type V intermediate filament network offering a stable reference signal in nuclear matrix preparations and chromatin fractionation assays.