Anti-Lamin A / C Antibody

A rabbit-derived polyclonal reagent from Antibodies.com targets Lamin A and Lamin C, two alternatively spliced isoforms of the nuclear intermediate filament protein encoded by the LMNA gene. Supplied as 100 µl of unconjugated antiserum, this primary antibody is validated for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows. The antibody cross-reacts with Lamin A/C homologs from human, mouse, and rat samples, making it useful for studies of nuclear envelope integrity, laminopathy disease models (including Hutchinson-Gilford progeria syndrome and Emery-Dreifuss muscular dystrophy), and stem cell differentiation programs where Lamin A/C expression marks mesenchymal commitment. Researchers studying chromatin organization, nuclear morphology during mitosis, or DNA damage response pathways use Lamin A/C as a loading control for nuclear-enriched fractions. For storage, keep the vial refrigerated and protect from light; aliquot upon arrival to limit freeze-thaw cycles and preserve epitope recognition across multiple experiments.