Anti-LAMB3 Antibody

This rabbit polyclonal primary antibody from Antibodies.com targets LAMB3, the beta-3 subunit of laminin-332, a basement membrane glycoprotein essential for epithelial cell adhesion and tissue integrity. Supplied as 100 µL of unconjugated reagent, it is validated for Western blot and immunohistochemistry on human samples, making it a practical tool for laboratories studying laminin expression in skin, mucosal, and tumor tissues.

LAMB3 mutations are well established as a molecular cause of junctional epidermolysis bullosa, so researchers working on inherited blistering disorders use antibodies of this kind to localize defective laminin-332 in patient biopsies and to compare expression between lesional and non-lesional tissue. In oncology, altered LAMB3 levels have been reported in squamous cell carcinomas and other epithelial tumors, where laminin-332 contributes to invasion and signaling through integrin receptors; the unconjugated format leaves the antibody open to custom labeling or signal amplification if a researcher needs higher sensitivity for a particular preparation.

Recommended refrigerated storage; protect from light and avoid repeated freeze-thaw cycles to preserve activity across multiple experiments. For research use only, not intended for diagnostic or therapeutic applications.