Anti-Kv7.1 Antibody

Anti-Kv7.1 Polyclonal Antibody for Cardiac and Epithelial Channel Research

This unconjugated rabbit polyclonal antibody targets the Kv7.1 voltage-gated potassium channel alpha subunit (KCNQ1), the pore-forming protein behind the slow delayed-rectifier I_Ks current that shapes cardiac action potential repolarization. Supplied by Antibodies.com as a 100 µl aliquot at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide at approximately pH 7.2, the reagent applies to Western blot and immunohistochemistry workflows on human, mouse, and rat samples, supporting studies of long QT syndrome type 1 (LQT1), short QT syndrome, familial atrial fibrillation, and channel trafficking in polarized epithelia where Kv7.1 assembles with KCNE beta subunits.

The polyclonal format presents multiple epitopes across the intracellular C-terminus and transmembrane regions, useful when probing channel variants, truncated splice isoforms, or trafficking mutants. Researchers studying I_Ks biophysics, auditory endolymph secretion, or intestinal potassium transport pair this reagent with KCNE1 co-immunoprecipitation to map Kv7.1 assembly. The azide-containing buffer tolerates routine refrigerated storage; aliquot upon arrival to limit freeze-thaw cycles and protect from light to preserve the unconjugated antibody across the working shelf life.