Anti-Kv1.1 Antibody

The Kv1.1 voltage-gated potassium channel, encoded by the KCNA1 gene, regulates neuronal excitability at juxtaparanodal regions of myelinated axons and within cerebellar circuits. This rabbit polyclonal antibody from Antibodies.com was generated against the channel and is supplied unconjugated, allowing flexible labeling with secondary reagents selected by the researcher.

The product is formulated at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.2, and ships as a 100 µl vial. Validated applications include Western blot (WB) and immunocytochemistry (ICC), with reactivity confirmed against human, mouse, and rat samples. These properties make the reagent useful for neuroscience research on channelopathies such as episodic ataxia type 1, peripheral nerve conduction, and synaptic integration.

For handling, aliquotting on receipt helps preserve activity across multiple freeze-thaw cycles and protects the concentrated stock from degradation. The polyclonal format provides recognition of multiple epitopes on the Kv1.1 channel, supporting consistent detection across experimental preparations. Research use only.