Anti-Ku-70/XRCC6 (7B1) Antibody

The Ku-70 subunit encoded by XRCC6 partners with Ku-80 to form the Ku heterodimer, the DNA-binding module of DNA-dependent protein kinase that drives non-homologous end joining and V(D)J recombination. This unconjugated clone 7B1 reagent from Antibodies.com is supplied as 100 µl of purified mouse monoclonal antibody in a 0.1M Tris-Glycine buffer at pH 7.4, with 150 mM NaCl, 50% glycerol, and 0.2% sodium azide as a preservative. Validated for Western blot, immunocytochemistry, and immunoprecipitation on human and monkey samples, the antibody supports studies of double-strand break repair, telomere maintenance, and chromatin-associated pools of the DNA-PK complex. Because the preparation is already in 50% glycerol, store at -20°C and dispense into single-use aliquots to avoid repeated freeze-thaw cycles that can damage the immunoglobulin.