Anti-Ku-70 (R586) Antibody

Rabbit polyclonal antibody targeting an epitope surrounding residue R586 of human Ku-70 (XRCC6), the 70 kDa subunit of the Ku heterodimer that partners with Ku-80 to drive non-homologous end joining (NHEJ) repair of DNA double-strand breaks.

Supplied by Antibodies.com as a 50 µl vial at 1 mg/ml in phosphate buffered saline (PBS) with 15 mM sodium azide at approximately pH 7.2, this unconjugated primary reagent is validated for western blot and immunohistochemistry across human, mouse, and rat samples.

Researchers apply it to study DNA damage signaling, V(D)J recombination, telomere maintenance, apoptosis regulation, and the assembly of the DNA-dependent protein kinase complex at break sites. The polyclonal host response broadens tolerance of minor epitope variation between species, supporting comparative work in rodent injury and knockout models. Store refrigerated; protect from light; avoid repeated freeze-thaw cycles.