Anti-Ku-70 Antibody

Raised in rabbit, this unconjugated polyclonal antibody recognizes the Ku70 nuclear antigen, a ~70 kDa subunit of the Ku heterodimer that partners with Ku80 to form the DNA-binding regulatory module of DNA-dependent protein kinase (DNA-PK). Antibodies.com supplies the reagent at 100 µl per vial, validated for Western blot and ELISA work against human, mouse, and rat samples.

Researchers studying non-homologous end joining, V(D)J recombination, telomere maintenance, and the cellular response to DNA double-strand breaks rely on Ku70 detection to monitor repair-complex assembly and to track changes in Ku expression across tumor and normal-tissue panels. The unconjugated format leaves the antibody open to custom secondary labeling, making it practical for immunoblotting of whole-cell lysates, immunoprecipitation of Ku-bound chromatin fragments, and ELISA-based quantification of Ku70 levels in experimental lysates.