Anti-KSR2 Antibody

This rabbit polyclonal antibody recognizes Kinase Suppressor of Ras 2 (KSR2), a scaffold protein that coordinates assembly of the RAF/MEK/ERK kinase cascade at the plasma membrane. KSR2 modulates Ras-dependent signal transduction and has been studied for its role in energy homeostasis, leptin signaling, and glucose metabolism, with loss-of-function variants in humans linked to obesity and altered insulin response.

Provided by Antibodies.com as a 100 µl aliquot of unconjugated polyclonal antiserum raised in rabbit, this reagent is validated for western blot and immunofluorescence workflows. The antibody specifically detects KSR2 in human and mouse samples without meaningful cross-reactivity with the closely related paralog KSR1, supporting use on cultured mammalian cell lines and tissue sections from both species. Researchers investigating MAPK pathway regulation, neuronal signaling, or metabolic disease mechanisms commonly rely on this reagent for protein-level detection in cell lysates and fixed-cell preparations.

Aliquot upon receipt and refrigerate working stocks; repeated freeze-thaw cycles of the original vial should be avoided. The unconjugated format allows downstream pairing with HRP-, fluorophore-, or biotin-conjugated secondary reagents, making it adaptable to chromogenic western blot, immunofluorescent imaging, and other immunoassay detection setups. Intended for research use only.