Anti-KRT81 Antibody

KRT81 encodes a type II hair keratin, also known by the legacy symbol KRTHB1, that is expressed predominantly in the matrix and shaft of hair follicles, the nail bed, and the filiform papillae of the tongue. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against the human protein and validated for Western blot and immunohistochemistry on human samples. Supplied as a 100 µL vial of polyclonal antiserum, the antibody recognizes the intermediate filament protein that heterodimerizes with type I partners such as KRT86 to build the cytoskeletal network of hard keratinizing epithelia. Loss-of-function variants in KRT81 are linked to monilethrix, an autosomal dominant hair shaft disorder characterized by beaded hairs and perifollicular keratosis. Investigators apply this reagent in hair biology, alopecia research, nail matrix studies, and ectodermal dysplasia modeling, where it can be paired with appropriate secondary antibodies for chromogenic or fluorescent detection in formalin-fixed tissue sections and immunoblotting of keratin-enriched lysates.