Anti-KRT2 Antibody

The primary antibody targets Keratin 2 (KRT2), a type II epithelial keratin that contributes to the structural integrity of upper-layer keratinocytes in stratified squamous epithelia. Produced by Antibodies.com as a rabbit polyclonal reagent, this unconjugated antibody is supplied in a 100 µl vial and is validated for Western blot (WB) and immunohistochemistry (IHC) applications on human samples.

Researchers studying epidermal differentiation, keratinization disorders, and skin barrier formation commonly employ anti-KRT2 antibodies to investigate conditions such as epidermolytic hyperkeratosis and ichthyosis bullosa of Siemens, both linked to mutations in the KRT2 gene. The polyclonal format recognizes multiple epitopes on the target, which can support detection across varied experimental conditions and help compensate for minor antigen variations.

For optimal stability, the antibody should be handled according to standard polyclonal serum protocols, with aliquoting recommended to limit freeze-thaw cycles and maintain reproducible performance across experiments.