Anti-KRIT1 Antibody

This rabbit polyclonal IgG reagent from Antibodies.com recognizes KRIT1 (also called CCM1), a scaffolding protein whose loss-of-function variants cause cerebral cavernous malformation type 1, a vascular lesion disorder affecting the central nervous system. The antibody is provided as a 50 µl vial in unconjugated format, ready for western blot and immunofluorescence experiments on human, mouse, and rat samples.

KRIT1 localizes to endothelial cell–cell junctions and contributes to Rho GTPase signaling and integrin-mediated adhesion through its partner ICAP1, making this reagent relevant for vascular biology, neurovascular pathology, and CCM1 signaling studies. The polyclonal nature enables multi-epitope recognition, useful when probing endogenous expression across tissues and primary endothelial cell cultures.

For short-term use, refrigerate the vial; for longer storage, freeze aliquots at −20 °C and limit freeze-thaw cycles to preserve antibody activity. The unconjugated format pairs with any standard anti-rabbit secondary antibody and detection chemistry for chromogenic, fluorescent, or chemiluminescent readout.