Anti-KRIT1 Antibody

This rabbit polyclonal antibody targets KRIT1 (Krev Interaction Trapped 1), the protein product of the CCM1 gene implicated in cerebral cavernous malformation type 1. Raised in rabbit and supplied as an unconjugated IgG, the reagent is validated for Western Blot (WB) and Immunofluorescence (IF) workflows on human, mouse, and rat samples.

KRIT1 localizes to endothelial cell-cell junctions and the cytosolic face of the plasma membrane, where it partners with ICAP1 and CCM2 to stabilize vascular tubes and help regulate Rho-GTPase signaling. Researchers studying cerebral cavernous malformations, brain microvascular integrity, and angiogenic remodeling use this antibody to probe endogenous KRIT1 distribution in cultured endothelial cells, tissue sections, and lysates. Each vial is supplied at 100 µL and should be stored at -20 °C in single-use aliquots to preserve performance across repeated freeze-thaw cycles.

From Antibodies.com, this lot is provided as a liquid primary antibody preparation intended for research use only, supporting reproducible detection of KRIT1 in immunoblot and immunofluorescence studies.