Anti-KRAS Antibody

Raised in Rabbit against the KRAS proto-oncogene GTPase, this unconjugated polyclonal primary antibody from Antibodies.com is supplied as 100 µL and validated for Western blot and immunohistochemistry on human samples. KRAS is a small GTP-binding protein in the RAS family that couples receptor tyrosine kinase signaling to the MAPK/ERK and PI3K/AKT cascades, and activating missense mutations at codons 12, 13, and 61 are among the most common oncogenic drivers in pancreatic ductal adenocarcinoma, colorectal carcinoma, and non-small cell lung cancer, making reliable anti-KRAS detection useful for tumor profiling, mutation-context studies, and downstream pathway analysis. Because the reagent is polyclonal, it binds multiple epitopes on KRAS, which can improve signal recovery on formalin-fixed paraffin-embedded sections and on blots where a monoclonal gives marginal or absent bands. Reported reactivity is Human, host is Rabbit, clonality is Polyclonal, and conjugate is Unconjugated. For research use only; not intended for diagnostic or therapeutic applications.