Anti-KLRB1 Antibody

Distributed by Antibodies.com as a primary antibody reagent, this rabbit polyclonal antibody recognizes the CD161/KLRB1 surface lectin-like receptor expressed on natural killer (NK) cells, NKT cells, mucosal-associated invariant T (MAIT) cells, and selected CD8+ T-cell subsets involved in innate-like immune surveillance. Supplied as 100 µl of unconjugated stock, the reagent supports Western blot (WB) and immunohistochemistry (IHC) workflows across human and mouse sample cohorts.

KLRB1 is a C-type lectin transmembrane glycoprotein that engages the ligand LLT1 (CLEC2D) and modulates NK cell cytotoxicity, T-cell proliferation, and inflammatory signaling. Researchers studying tumor-infiltrating lymphocytes, mucosal immunity, autoimmune inflammation, viral response pathways, and transplantation immunology use anti-CD161 antibodies to identify, enumerate, and characterize these lymphocyte populations in tissue sections and lysates.

Recommended handling is to refrigerate the vial, aliquot on first use, and limit freeze-thaw cycles to preserve polyclonal reactivity over the working shelf life. Each vial is intended for research use only and is not validated for diagnostic or therapeutic applications. Validation data and supporting literature references are available on the Antibodies.com product page.