Anti-KLHL3 Antibody

KLHL3 is a member of the Kelch-like protein family that operates as a substrate adaptor within a Cullin3-based E3 ubiquitin ligase complex, recruiting proteins such as WNK kinases for ubiquitin-mediated degradation and connecting this pathway to renal ion transport regulation, blood pressure homeostasis, and pseudohypoaldosteronism type II.

The Antibodies.com reagent is a rabbit polyclonal antibody supplied as 100 µl of unconjugated liquid in a single vial, raised against the KLHL3 target and validated for Western blot, immunohistochemistry, and immunofluorescence detection on human and mouse samples. Researchers studying KLHL3 expression, Cullin3-mediated ubiquitination, or related BTB-Kelch signaling biology can apply the antibody across cell culture and tissue-based workflows, with aliquoting recommended after first use to limit freeze-thaw exposure and preserve long-term reactivity for repeated staining and blotting experiments.