Anti-KLHL26 Antibody

Kelch-like protein 26 (KLHL26) is a 615-amino-acid, ~68.1 kDa BTB-BACK-Kelch family member that serves as a substrate adaptor for the Cullin3-based E3 ubiquitin ligase complex, contributing to ubiquitin-mediated turnover of target proteins in cardiomyocytes and other tissues. The unconjugated rabbit polyclonal IgG reagent supplied by Antibodies.com in a 200 µl vial is intended for Western Blot detection of endogenous KLHL26 in human and rat cell and tissue lysates. Because KLHL26 carries a BTB/POZ domain together with a C-terminal Kelch repeat β-propeller, antibody recognition of this adaptor has become relevant to studies of the ubiquitin-proteasome system, p53-responsive transcriptional programs regulated through intronic fuzzy tandem repeats, and rare cardiac phenotypes such as Ebstein's anomaly with left ventricular noncompaction, where a KLHL26 p.R237C variant has been shown to disrupt electrostatic contact with CUL3. Researchers working on these questions use immunoblotting workflows with the unconjugated format to pair their own choice of HRP- or fluorophore-conjugated secondary reagents, supporting flexible detection across lysate preparations. For long-term storage, freeze at -20 °C in working aliquots to limit freeze-thaw cycles. Research use only.