Anti-KLC1 Antibody

This rabbit polyclonal antibody from Antibodies.com targets Kinesin Light Chain 1 (KLC1), an accessory subunit of the conventional kinesin-1 motor complex that drives anterograde microtubule-based transport of membrane-bound organelles, vesicles, and protein cargo throughout the cytoplasm of neurons and non-neuronal cells. Raised in rabbit and supplied as an unconjugated IgG preparation in a 100 µl vial, the reagent is formatted for standard immunodetection workflows without the need for pre-conjugation.

The antibody has been validated for Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF). It recognizes KLC1 from Human, Mouse, and Rat samples, supporting comparative studies that span rodent disease models and human tissue panels. Because KLC1 mediates cargo recognition through its C-terminal tetratricopeptide repeat (TPR) domain and has been identified as a caspase substrate relevant to neurodegeneration, this reagent is used by laboratories investigating axonal transport deficits, neuronal viability, and cytoskeletal signaling in conditions such as Alzheimer's disease.

As a polyclonal reagent, the antibody binds multiple epitopes across the KLC1 molecule, increasing the likelihood of a positive signal even when one epitope is masked by aldehyde fixation in IHC/IF protocols. The unconjugated format gives researchers flexibility to couple the antibody to their preferred fluorophore, biotin, or HRP for custom detection chemistry. For handling, refrigerate the vial on arrival, aliquot into working volumes, and avoid repeated freeze-thaw cycles to preserve antibody activity over extended storage.