Anti-KISS1 Antibody

This rabbit polyclonal antibody from Antibodies.com recognizes KISS1, the gene encoding the kisspeptin precursor protein, which is proteolytically processed into shorter biologically active peptides including kisspeptin-10, -13, and -54. Kisspeptin signaling through the GPR54/KISS1R receptor is a central driver of the neuroendocrine axis that controls GnRH release and the timing of puberty onset. KISS1 was originally characterized as a metastasis suppressor in melanoma cell lines, and its expression continues to be investigated in reproductive biology, placental function, and tumor invasion research.

The unconjugated reagent is supplied as a 100 µl liquid aliquot and is validated for western blot and immunohistochemistry workflows on human and mouse tissue samples. Common applications include detection of the endogenous kisspeptin precursor in hypothalamic sections, placental preparations, and tumor-derived cell lines, supporting studies of GPR54 signaling, trophoblast biology, and metastatic competence.