Anti-KIR2DS4 Antibody

Raised in rabbit, this unconjugated polyclonal antibody targets the activating immunoreceptor KIR2DS4, a member of the killer-cell immunoglobulin-like receptor (KIR) family expressed on natural killer (NK) cells and on a subset of cytotoxic T lymphocytes. KIR2DS4 transduces activating signals through association with the DAP12 adaptor and has been characterized for its recognition of HLA class I molecules, including HLA-A*11, making it a relevant reagent for studies of NK-cell education, innate immune regulation, and HLA ligand recognition in human samples. Supplied at 100 µl volume in a vial, the antibody is validated for Western blot and immunohistochemistry workflows, supporting analysis of KIR expression patterns in lymphoid tissue, tumor-infiltrating lymphocytes, and NK-cell line models. Researchers working in reproductive immunology, viral immunity, and transplantation biology can use this reagent from Antibodies.com to profile KIR2DS4 expression alongside inhibitory KIR family members such as KIR2DL1 and KIR2DL3. The polyclonal format increases the likelihood of detecting multiple epitopes across the KIR2DS4 extracellular Ig-like domains, which is useful given the extensive allelic polymorphism that has been reported within the KIR gene complex on chromosome 19q13.4.