Anti-KIR2DL3 Antibody

Primary antibody reagents directed against the inhibitory natural killer (NK) cell receptor KIR2DL3, also known as CD158b or NKAT2, support characterization of human lymphocyte populations in immunology research. This Antibodies.com reagent is supplied as an unconjugated rabbit polyclonal antibody at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, packaged as a 100 µl vial that provides enough material for multiple experimental runs.

KIR2DL3 belongs to the killer cell immunoglobulin-like receptor (KIR) family and recognizes HLA-C group 1 alleles, delivering an inhibitory signal that modulates NK cell cytotoxicity. The product is validated for Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) workflows on human tissue and cell samples. Researchers use this reagent to profile NK and CD8+ T cell subsets, examine maternal-fetal immune tolerance linked to KIR haplotypes, and explore receptor-ligand interactions relevant to hematopoietic stem cell transplantation and viral immunity studies.

The polyclonal antibody recognizes multiple epitopes across the extracellular Ig-like domains, which is useful when surveying donor-to-donor KIR2DL3 variation. Store refrigerated and protect from light; aliquot to limit repeated freeze-thaw cycles. Sodium azide is included as a preservative at 0.1%.